For this reason there has been renewed interest in alternate separation routes. Most of these alternative production processes require separation techniques capable of providing clinical grade 99mTc from low specific activity 99Mo or irradiated Mo targets. The reduced availability of F 99Mo and consequently the shortage of 99Mo/99mTc column generators in the recent past have resurrected interest in the production of 99Mo as well as 99mTc by alternate routes. Due to the success of column chromatographic separation using acidic alumina coupled with high specific activity fission 99Mo (F 99Mo) for production of 99Mo/99mTc generators, however, most technologies until recently have generated little interest. Several strategies for the effective separation of 99mTc from 99Mo have been developed and validated.
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